SPINK-5 GENE POLYMORPHISM AS A GENETIC FACTOR IN SCLERODERMA AND CHRONIC LUPUS ERYTHEMATOSUS DEVELOPMENT

Abstract

Оn the ground of genetic researches the necessity of SPINK-5 gene polymorphism analysis has been shown. 174 patients with different stages and severity levels of scleroderma and 76 patients with chronic lupus erythematosus with different stages and severity levels were genotyped. The association between allele A, AA genotype and GG genotype of SPINK-5 gene and studied pathologies was shown in the work. Allele A causes high-risk of scleroderma, AA genotype causes high-risk of chronic lupus erythematosus and genotype GG causes reducer risk of occurrence of studied diseases. In men genetic factors play more important role in development of scleroderma and chronic lupus erythematosus, than in women.