Hemostasis Disorders in Systemic Connective Tissue Diseases with Cutaneous Manifestations

Abstract

The article examines hemostatic disorders in systemic scleroderma associated with generalized microvascular lesions, vasoconstriction, and altered blood rheology. It describes the relationship between activation of the vascular-platelet and coagulation pathways, impairment of anticoagulant mechanisms, and suppression of fibrinolysis, forming a self-sustaining cycle of disseminated intravascular coagulation. In 30 examined patients, increased fibrinogen, reduced spontaneous lysis, and other signs of hypercoagulation, chronic disseminated intravascular coagulation, and impaired fibrinolysis were identified. Comprehensive hemostasis assessment may facilitate early recognition of microcirculatory disorders and disseminated intravascular coagulation.